Deleterious effects of high magnesium diets and beneficial effects of high potassium diets in hypertensive stroke-prone rats
Ganguli, M.; Tobian, L.; Sugimoto, T.
Magnesium Research 3(4): 255-261
1990
ISSN/ISBN: 0953-1424 PMID: 2132672 Document Number: 357965
The effect of varying amounts of dietary magnesium (Mg) in conjunction with potassium (K) on hypertension and stroke mortality in hypertensive stroke-prone (SHRsp) rats was studied. These results show that high K (2.1%) diets strongly protect against stroke mortality and rises of blood pressure, while high Mg (0.26%) diets appeared to increase stroke mortality and accelerate the rise of blood pressure in SHRsp rats. Similarly, medium high (1.3%) levels of K in the diet significantly reduced blood pressure and stroke mortality but not nearly as much as the 2.1% K in the high K diet.