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Vitamin a and microsomal membranes: the effect of retinol deficiency on lipid microviscosity and phospholipid turnover in rat liver microsomes

Kon', I.I.; Sokolov, A.I.; Filatov, I.I.; Deev, A.I.; Gapparov, M.M.

Biokhimiia 55(6): 982-987

1990

ISSN/ISBN: 0320-9725
PMID: 2207212
Document Number: 353878
Studies with the use of the fluorescent probe pyrene revealed that vitamin A deficiency in maturing male rats results in the increased microviscosity of liver lipids. This effect seems to be due to changes in the lipid composition of microsomal membranes (increased cholesterol/phospholipid ratio and lowered polyunsaturated fatty acid content) as well as to the low level of retinol. Analysis of microsomal phospholipids labeled with [3H]palmitate and [14C]glycerol revealed that vitamin A deficiency accelerates the turnover of the glycerol skeleton but sharply decelerates that of fatty acid residues. It is concluded that the observed effect of retinol on the structural and functional properties of biological membranes is due to its ability to control the microviscosity and turnover of membrane lipids.

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Ternovoĭ, V.A.; Mikhaĭlov, I.V.; Iakovlev, V.M. 1993: Effect of acute hypoxia on the phospholipid composition of the cell, microsomal and mitochondrial membranes of rat brain and liver Voprosy Meditsinskoi Khimii 39(5): 50-52
Ozaki, S. 1974: Effect of lipids on liver microsomal membranes. (1) Studies of a relationship between delipidation of liver microsomes with the various organic solvents and cytochrome c reductase activity linked to reduced nicotinamide adenine dinucleotide Hokkaido Journal of Medical Science 49(4): 326-336
Pentiuk, A.A. 1989: The effect of vitamin e deficiency on enzyme activity and the status of the membrane fraction of rat liver microsomes Ukrainskii Biokhimicheskii Zhurnal 61(4): 87-93
Borodin, E.A.; Dobretsov, G.E.; Karasevich, E.I.; Karuzina, I.I.; Kariakin, A.V. 1981: Effect of incorporation and removal of cholesterol on the lipid bilayer viscosity and the rate of oxidative reactions in rat liver microsomal membranes Biokhimiia 46(6): 1109-1118
Gevorkian, E.S.; Tadevosian, I.V.; Iavroian, Z.V.; Gevorkian, G.A. 1986: Effect of hydrocortisone on the phospholipid composition and activity of various enzymes of phospholipid metabolism in the nuclear membranes of the rat liver Biokhimiia 51(10): 1630-1634
Dazzi, E.; Carbini, L.; Padalino, A.; Scarpa, A.L.; Lantini, T. 1978: Uptake of retinol-C14 into liver mitochondrial membranes and erythrocyte stroma of albino rats on a vitamin A-free diet Acta Vitaminologica et Enzymologica 32(1-4): 17-20
Gubskiy, I.I.; Paramonova, G.I.; Boldeskul, A.E.; Primak, R.G.; Bogdanova, L.A.; Zadorina, O.V.; Litvinova, N.V. 1992: Peroxide modification of membranes and isomorphic composition of cytochrome P-450 of rat liver microsomes during antioxidant deficiency Ukrainskii Biokhimicheskii Zhurnal 64(1): 98-105
Van Stuijvenberg, M.E.; Schoeman, S.E.; Nel, J.; Lombard, C.J.; Dhansay, M.A. 2017: Serum retinol in post-partum mothers and newborns from an impoverished South African community where liver is frequently eaten and vitamin a deficiency is absent Maternal and Child Nutrition 13(1)
Araujo, R.L.; Borges, E.L.; Silva, J.D.A.B.; Vieira, E.C. 1978: Comparison between the use of massive amounts of vitamin A and the use of sugar fortified with retinol to combat vitamin A deficiency Revista Associacao Brasileira das Industrias da Alimentacao/Setor de Alimentos Calorico Proteicos 37: 2 . . . 13
Shih, T.W.; Hill, D.L. 1991: Conversion of retinol to retinal by rat liver microsomes Drug Metabolism and Disposition: the Biological Fate of Chemicals 19(2): 332-335
Hostetler, K.Y.; Zenner, B.D.; Morris, H.P. 1979: Phospholipid content of mitochondrial and microsomal membranes from Morris hepatomas of varying growth rates Cancer Research 39(8): 2978-2983
Gubskiĭ, I.I.; Boldeskul, A.E.; Primak, R.G.; Zadorina, O.V. 1989: The effect of alpha-tocopherol and ionol on the physical structure of the membranes of rat liver microsomes under conditions of antioxidant insufficiency Ukrainskii Biokhimicheskii Zhurnal 61(4): 94-99
Arkhipenko, I.V.; Dobrina, S.K.; Kagan, V.E.; Kozlov, I.P.; Nadirov, N.K.; Pisarev, V.A.; Ritov, V.B.; Khafizov, R.K. 1977: Mechanisms of stabilizing effect of vitamin e against lipid peroxidation in biological membranes Biokhimiia 42(8): 1525-1531
Gronowska-Senger, A.; Kierzkowski, J. 1981: Effect of various doses of vitamin a on vitamin e and lipid levels in the liver and plasma of rats Roczniki Panstwowego Zakladu Higieny 32(2): 123-128
Legon'kova, L.F.; Abakumov, G.Z.; Bushma, M.I.; Lukienko, P.I. 1990: Changes in UDP-glucuronosyl-, glutathione-S-transferase and lipid peroxidation in rat liver microsomes during gamma-irradiation and protective effect of alpha-tocopherol Voprosy Meditsinskoi Khimii 36(3): 26-28
Diatlovitskaia, E.V.; Petkova, D.K.; Lemenovskaia, A.F.; Bergel'son, L.D. 1982: Lipid dependence of cytochrome P-450 activity in rat liver microsomes using lipid exchange proteins Biokhimiia 47(2): 216-220
Adoncecchi, L.; Marrocco, W.; Suraci, C.; Pecora, P.; Gallinella, B.; Porrà, R.; Cavina, G. 1984: Effect of renal and liver failure on blood levels of vitamin A, its precursor (beta-carotene) and its carrier proteins (prealbumin and retinol binding protein) Bollettino della Societa Italiana di Biologia Sperimentale 60(4): 881-886
Gallenkamp, H.; Brachtel, D.; Richter, E. 1973: Relations between phospholipid composition of plasma and liver microsomes in experimental cholestasis and hepatitis Verhandlungen der Deutschen Gesellschaft für Innere Medizin 79: 930-933
Grossman, C.P.; Suttie, J.W. 1992: Synthesis of fluoro- and hydroxy-derivatives of vitamin K as substrates or inhibitors of the liver microsomal vitamin K-dependent carboxylase Biofactors 3(3): 205-209
Bagchi, M.; Mukherjee, S.; Basu, M.K. 1993: Lipid peroxidation in hepatic microsomal membranes isolated from mice in health and in experimental leishmaniasis Indian Journal of Biochemistry and Biophysics 30(5): 277-281