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Effect of incorporation and removal of cholesterol on the lipid bilayer viscosity and the rate of oxidative reactions in rat liver microsomal membranes

Borodin, E.A.; Dobretsov, G.E.; Karasevich, E.I.; Karuzina, I.I.; Kariakin, A.V.

Biokhimiia 46(6): 1109-1118

1981

ISSN/ISBN: 0320-9725
PMID: 7260196
Document Number: 181794
The interrelationship between the lipid bilayer viscosity and the rate of oxidative reactions in rat liver microsomal membranes were investigated. The viscosity of the lipid bilayer is increased upon incorporation of cholesterol into the microsomes and is decreased upon its removal. This results in a corresponding decrease and increase of the rate of cytochrome b5 reduction by NAD(P)H. The rates of cytochrome P-450 reduction and oxidation of dimethylaniline, aniline, p-nitroanisol and NAD(P)H, as well as those of oxygen uptake and lipid peroxidation do not depend on the bilayer viscosity. Hence only the reactions of cytochrome b5 reduction by NADH- and NADPH-specific flavoproteins are diffusion-dependent processes in the microsomal oxidation chain.

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Baranik, E.A.; Girnyk, S.A.; Tovstiak, V.V. 1988: Stimulation of gramicidin incorporation into lipid bilayer membranes by ultrasound Biofizika 33(2): 364-366
Kon', I.I.; Sokolov, A.I.; Filatov, I.I.; Deev, A.I.; Gapparov, M.M. 1990: Vitamin a and microsomal membranes: the effect of retinol deficiency on lipid microviscosity and phospholipid turnover in rat liver microsomes Biokhimiia 55(6): 982-987
Antonenko, I.N.; Iaguzhinskiĭ, L.S. 1982: Generation of potential on bilayer lipid membrane in proton combination-separation reactions in the layers adjacent to the membranes Biofizika 27(4): 635-640
Semenkova, G.N.; Kedits, G.; Cherenkevich, S.N.; Khmel'nitskiĭ, A.I. 1984: Effect of ozone on the permeability of flat bilayer lipid membranes Biofizika 29(2): 323-325
Seleznev, E.A.; Simonov, A.N.; Tverdislov, V.A.; Kharitonenkov, I.G. 1990: Effect of influenza virus proteins on the physical properties of lipid bilayer membranes Biofizika 35(5): 880-881
Kratz, F. 1978: Microsomal oxidative foreign-substance degradation by the human liver. Oxidative foreign-substance degradation by microsomal fractions of the liver withdrawn by needle biopsy, illustrated on the example of coumarin-7-hydroxylase and 7-ethoxycoumarin hydroxylase in persons with healthy livers and various liver diseases Fortschritte der Medizin 96(8): 393-397
Williams, M.T.; Gaylor, J.L.; Morris, H.P. 1977: Investigation of the rate-determining microsomal reaction of cholesterol biosynthesis from lanosterol in Morris hepatomas and liver Cancer Research 37(5): 1377-1383
Zil'bershteĭn, A.I. 1986: Analysis of displacement currents in lipid bilayer membranes Biofizika 31(2): 345-346
Tien, H.T.; Salamon, Z. 1990: Self-assembling bilayer lipid membranes on solid support Biotechnology and Applied Biochemistry 12(5): 478-484
Chernyĭ, V.V.; Kozlov, M.M.; Sokolov, V.S.; Ermakov, I.A.; Markin, V.S. 1982: Adsorption of 1-anilino-3-naphthalenesulfonate on bilayer lipid membranes Biofizika 27(5): 812-817
Hianik, T.; Fajkus, M.; Tarus, B.; Sargent, D.F.; Markin, V.S.; Landers, D.F. 2000: The changes of capacitance relaxation of bilayer lipid membranes induced by chlorpromazine Die Pharmazie 55(7): 546-547
Martseniuk, O.V.; Perova, N.V.; Misharin, A.I.; Antonov, I.V.; Kuznetsov, A.S. 1987: Interaction of plasma lipoproteins and apolipoproteins with lipid bilayer membranes Biofizika 32(2): 280-284
Viriasov, S.N.; Perelygin, V.V. 1984: Specific electric resistance of a narrow gap between two lipid bilayer membranes Biofizika 29(5): 792-795
Markin, V.S.; Sokolov, V.S.; Boguslavskiĭ, L.I.; Iaguzhinskiĭ, L.S. 1977: Dimeric mechanism of the work of nigericin in bilayer lipid membranes Biofizika 22(1): 48-53
Smirnov, A.A.; Putvinskiĭ, A.V.; Roshchupkin, D.I.; Vladimirov, I.A. 1981: Irreversible damage of lipid bilayer membranes in a state of electrical breakdown Biofizika 26(1): 140-142
Budker, V.G.; Markushin, I.Ia.; Suiushev, V.A. 1986: Changes in the electrical characteristics of bilayer lipid membranes during adsorption of heparin in the presence of Ca2+ Biofizika 31(2): 359-360
Ozaki, S. 1974: Effect of lipids on liver microsomal membranes. (1) Studies of a relationship between delipidation of liver microsomes with the various organic solvents and cytochrome c reductase activity linked to reduced nicotinamide adenine dinucleotide Hokkaido Journal of Medical Science 49(4): 326-336
Mason, R.P.; Moisey, D.M.; Shajenko, L. 1992: Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer Molecular Pharmacology 41(2): 315-321
Ternovoĭ, V.A.; Mikhaĭlov, I.V.; Iakovlev, V.M. 1993: Effect of acute hypoxia on the phospholipid composition of the cell, microsomal and mitochondrial membranes of rat brain and liver Voprosy Meditsinskoi Khimii 39(5): 50-52
Mol'nar, A.A.; Petrov, V.V.; Predvoditelev, D.A.; Antonov, B.F. 1981: Initiation of anion-selective ionic channels in bilayer membranes at lipid phase transitions Biofizika 26(3): 538-540