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Determination of the concentration of cytochrome c and its antibodies in the blood serum for the diagnosis and prognosis of complications in myocardial infarct patients

Gvatua, N.A.; Komissarenko, S.V.; Skok, M.V.; Solonenko, I.N.; Veselovskaia, L.D.; Galitskaia, A.K.

Terapevticheskii Arkhiv 62(4): 58-61

1990

ISSN/ISBN: 0040-3660
PMID: 2168094
Document Number: 350304
EIA was used to demonstrate that the development of acute ischemia of the heart muscle progressing to necrosis is accompanied by an increase of the concentration of cytochrome c and antibodies against cytochrome c in the blood serum. As regards its specificity and sensitivity, the alteration in the antibody concentration is comparable with that in the myoglobin concentration but it is marked 1 to 3 hours earlier. The high level of antibodies against cytochrome c remaining unchanged for 2 to 3 days in myocardial infarction patients attests to the possibility of a complicated, often relapsing course of the disease. The test for determining antibodies against cytochrome c may be recommended for the control over the patient's status and forecasting the course of myocardial infarction.

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