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The protective properties of a porin from the outer membrane of Yersinia pseudotuberculosis

Timchenko, N.F.; Novikova, O.D.; Pavlova, T.N.; Venediktov, V.S.; Solov'eva, T.F.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 11: 48-50

1990

ISSN/ISBN: 0372-9311
PMID: 1965874
Document Number: 347831
The protective properties of the species-specific pore-forming polypeptide of Y. pseudotuberculosis outer membrane (porin) were studied. The study showed that 80-90% of mice immunized with porin survived after challenge with 10-30 LD50 of Y. pseudotuberculosis, serovars 1 and 3. The LD50 of the preparation exceeded its ED50 more than 100-fold. Immunization made in two injections was more effective than immunization in one injection. The immunization of the animals with porin led to an increase in the activity of peritoneal exudate macrophages with respect to Y. pseudotuberculosis, serovars 1 and 3.

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