Oligoribonucleotide synthesis by use of the 2- (methylthio) -phenylthiomethyl (MPTM) group
Sekine, M.; Nakanishi, T.
Nucleic Acids Symposium Series 21: 33-34
1989
ISSN/ISBN: 0261-3166 PMID: 2608469 Document Number: 347179
The 2-(methylthio)phenylthiomethyl (MPTM) group was developed as a new type of 2'-hydroxyl protecting group in oligoribonucleotide synthesis. The building monomer units of uridine and cytidine for the phosphotriester approach were synthesized from 2'-O-(1,3-benzodithiol-2-yl)-3',5'-O- (1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)uridine and successfully utilized for the synthesis of CpUpG.
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