Influence of prenatal administration of cadmium on postnatal development and inducibility of hepatic monooxygenases in rats
Jahn, F.; Klinger, W.
Pharmacology and Toxicology 64(3): 291-292
1989
ISSN/ISBN: 0901-9928 PMID: 2786197 Document Number: 346914
Cadmium inhibits hepatic monooxygenases in rats of different ages. But also in the offspring of dams which had received cadmium during pregnancy changes in biotransformation activities and their inducibilities could be observed. In the 30- and 60-day-old offspring a decrease in the inducibility of ethoxyresorufin O-deethylation by the specific inducer .beta.-naphthoflavone could be demonstrated, whereas cytochrome P-450 concentration, ethylmorphine N-demethylation and ethoxycoumarin O-deethylation were not influenced.