Effects of zinc diethyldithiocarbamate on the prenatal and postnatal developments of the rats
Nakaura, S.; Tanaka, S.; Kawashima, K.; Takanaka, A.; Omori, Y.
Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 1984(102): 55-61
1984
ISSN/ISBN: 0077-4715 PMID: 6099742 Document Number: 421
Zinc diethyldithiocarbamate (ZDEC) was suspended in olive oil and was given by oral intubation to pregnant Wistar rats in daily doses of 31.25, 62.5, 125 and 250 mg/kg during days 7 through 15 of gestation, and the effects of ZDEC on the prenatal and postnatal developments were examined. No changes in maternal body weight gain, food consumption and general symptoms were found in the groups of 62.5 mg/kg of ZDEC and below. In the 125 mg/kg group, slight diarrhea was observed. In the highest dose group of 250 mg/kg, maternal body weight gain and food consumption were markedly suppressed, toxic symptoms such as piloerection, diarrhea and syntexis were seen and 7 out of 22 dams died. At the 20th day of gestation, there was no evidence of an increase in fetal death or of malformation attributable to the treatment with ZDEC in any of the dose levels examined. In the postnatal examination, the development of the offspring were well maintained at dose levels of 125 mg/kg and below without any evidence of disorders attributable to the treatment on morphological examination. ZDEC has no teratogenic effect in rats under the present experimental conditions, although the compound, at dose levels of 125 and 250 mg/kg, elicited maternal toxicity.
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