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Effects of suprofen on renal function in patients with rheumatoid arthritis

Malandrino, S.; Angelini, M.; Baldini, L.; Barenghi, L.; Borsa, M.; Carrabba, M.; Ceriotti, F.; Tonon, G.C.

International Journal of Clinical Pharmacology Research 7(4): 259-263

1987

ISSN/ISBN: 0251-1649
PMID: 3474214
Document Number: 420
Suprofen is a new potent analgesic with antiinflammatory properties that appears to inhibit prostaglandin synthetase in a tissue-selective manner, having relatively little effect on the kidneys of experimental animals. The effects were studied of one week of treatment of rheumatoid arthritis patients with suprofen or ibuprofen on Na+ and K+ excretion, creainine clearance, urinary enzymes that are markers for tubular damage, and urinary prostaglandins such as PGE2 and 6-keto PGF1.alpha. (a stable metabolite of prostacyclin). Neither compound caused changes in renal function related to the week of treatment, but significant decreases in prostaglandins were observed: this change was fully reversible after discontinuation of the drug.

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Effects of suprofen on renal function in patients with rheumatoid arthritis

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