Renal side effects of treatment with cyclosporin A in rheumatoid arthritis and after bone marrow transplantation
Marbet, U.A.; Graf, U.; Mihatsch, M.J.; Gratwohl, A.; Müller, W.; Thiel, G.
Schweizerische Medizinische Wochenschrift 110(52): 2017-2020
1980
ISSN/ISBN: 0036-7672 PMID: 7025192 Document Number: 166779
Renal function was studied prospectively in 6 patients with rheumatoid arthritis, and non-prospectively in 5 patients after bone marrow transplantation. Both groups were treated with cyclosporin A. Functionally and histologically, the results suggest tubulotoxicity of cyclosporin A, which seems to be dose-related and reversible. Also found in the urine of these patients were yellow, as yet undescribed, crystalline bodies often included in casts.