Cadmium inhibition of in vitro hepatic oxidative drug metabolism in the rat: comparison between ionic cadmium and cadmium-thionein
Roberts, S.A.; Schnell, R.C.
Research Communications in Chemical Pathology and Pharmacology 35(2): 349-352
1982
ISSN/ISBN: 0034-5164 PMID: 7071421 Document Number: 186442
The effectiveness of cadmium added in vitro in inhibiting the microsomal oxidative metabolism of ethylmorphine or aniline in rat hepatic microsomes was markedly decreased if the metal was added as cadmium-thionein when compared to ionic cadmium. These data are consistent with the hypothesis that cadmium thionein is less active biologically than ionic cadmium.
Document emailed within 1 workday
Related Documents
Barański, B.; Opacka, J.; Wrońska-Nofer, T.; Trzcinka-Ochocka, M.; Sitarek, K.; Matczak, W. 1983: Effect of inhalation exposure to cadmium oxide on arterial blood pressure, lipid metabolism and tissue cadmium concentration in rats Medycyna Pracy 34(1): 11-19Bassendowska-Karska, E.; Zawadzka-Kos, M. 1989: Effect of the combined action of cadmium and ethyl alcohol or cadmium and acetaldehyde on the genesis of sister chromatid exchange in lymphocytes of human blood in vitro Roczniki Panstwowego Zakladu Higieny 40(1): 53-57
Feldman, S.L.; Squibb, K.S.; Cousins, R.J. 1978: Degradation of cadmium-thionein in rat liver and kidney Journal of Environmental Pathology and Toxicology 2(2): 463-472
Gale, G.R.; Atkins, L.M.; Walker, E.M.; Smith, A.B. 1983: Factors influencing cadmium mobilization by diethyldithiocarbamate: chelator dose, cadmium burden, and sex Annals of Clinical and Laboratory Science 13(2): 107-114
Chen, Y.; Li, T.-q.; Yang, X.-e.; Jin, Y.-f. 2009: Differences in cadmium absorption and accumulation of Brassica varieties on cadmium-polluted soil Ying Yong Sheng Tai Xue Bao 20(3): 736-740
Korkeala, H. 1980: The effect of vitamin e on the toxicity of cadmium in cadmium-sensitive Staphylococcus aureus Acta Veterinaria Scandinavica 21(2): 224-228
Dogra, S.; Khanna, A.K.; Waseem, M.; Kaw, J.L. 2001: Tissue cadmium and locomotor behavior following acute inhalation exposure to cadmium aerosol in rats Veterinary and Human Toxicology 43(3): 176-178
Cook, G.; Vredevoe, D.; Levy, L. 1984: Influence of cadmium on isolated peritoneal macrophage populations: I. Cadmium interferes with Fc receptor function Proceedings of the Western Pharmacology Society 27: 481-486
Squibb, K.S.; Pritchard, J.B.; Fowler, B.A. 1984: Cadmium-Metallothionein nephropathy: relationships between ultrastructural/biochemical alterations and intracellular cadmium binding Journal of Pharmacology and Experimental Therapeutics 229(1): 311-321
Swaddiwudhipong, W.; Limpatanachote, P.; Mahasakpan, P.; Krintratun, S.; Padungtod, C. 2007: Cadmium-exposed population in Mae Sot District, Tak Province: 1. Prevalence of high urinary cadmium levels in the adults Journal of the Medical Association of Thailand 90(1): 143-148
Swaddiwudhipong, W.; Mahasakpan, P.; Funkhiew, T.; Limpatanachote, P. 2010: Changes in cadmium exposure among persons living in cadmium-contaminated areas in northwestern Thailand: a five-year follow-up Journal of the Medical Association of Thailand 93(10): 1217-1222
Limpatanachote, P.; Swaddiwudhipong, W.; Nishijo, M.; Honda, R.; Mahasakpan, P.; Nambunmee, K.; Ruangyuttikarn, W. 2010: Cadmium-exposed population in Mae Sot District, Tak Province: 4 bone mineral density in persons with high cadmium exposure Journal of the Medical Association of Thailand 93(12): 1451-1457
Vorob'eva, R.S.; Bubnova, N.I. 1981: Action on the body of elemental cadmium and cadmium telluride Gigiena Truda i Professional'nye Zabolevaniya (2): 42-43
Singh, P.K.; Tewari, R.K. 2003: Cadmium toxicity induced changes in plant water relations and oxidative metabolism of Brassica juncea L. plants Journal of Environmental Biology 24(1): 107-112
Leelavinothan, P.; Kalist, S. 2011: Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study European Review for Medical and Pharmacological Sciences 15(9): 992-1002
Pence, D.H.; Schnell, R.C. 1980: Cadmium-induced inhibition of zoxazolamine metabolism in male and female rats Research Communications in Chemical Pathology and Pharmacology 27(2): 413-416
Swaddiwudhipong, W.; Limpatanachote, P.; Nishijo, M.; Honda, R.; Mahasakpan, P.; Krintratun, S. 2010: Cadmium-exposed population in Mae Sot district, Tak province: 3. Associations between urinary cadmium and renal dysfunction, hypertension, diabetes, and urinary stones Journal of the Medical Association of Thailand 93(2): 231-238
Nomiyama, K.; Liu, S.J.; Nomiyama, H. 1992: Critical levels of blood and urinary cadmium, urinary beta 2-microglobulin and retinol-binding protein for monitoring cadmium health effects Iarc Scientific Publications 118: 325-340
Gale, G.R.; Smith, A.B.; Atkins, L.M.; Jones, M.M. 1985: Effects of diethyldithiocarbamate and N-methyl-N-dithiocarboxyglucamine on murine hepatic cadmium-metallothionein in vitro Research Communications in Chemical Pathology and Pharmacology 49(3): 423-434
Pillai, A.; Laxmipriya; Rawal, A.; Gupta, S. 2002: Effect of low level exposure of lead and cadmium on hepatic estradiol metabolism in female rats Indian Journal of Experimental Biology 40(7): 807-811