Cadmium-induced inhibition of zoxazolamine metabolism in male and female rats
Pence, D.H.; Schnell, R.C.
Research Communications in Chemical Pathology and Pharmacology 27(2): 413-416
1980
ISSN/ISBN: 0034-5164 PMID: 7367758 Document Number: 166312
Pretreatment of rats with cadmium potentiates the duration of hexobarbital hypnosis and inhibits the rate of hepatic hexobarbital metabolism in male and female rats. In contrast, treatment with cadmium pe and female rats. Thus, sex-related differences in cadmium inhibition of hepatic drug metabolism is apparently substrate dependent.
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