Modulation of zoxazolamine metabolism in carrageenan-induced inflammation in rats
Ishikawa, M.; Sasaki, K.; Yakayanagi, Y.; Sasaki, K.
Research Communications in Chemical Pathology and Pharmacology 70(3): 367-370
1990
ISSN/ISBN: 0034-5164 PMID: 2093215 Document Number: 367139
In male rats bearing carrageenan-induced paw edema twenty-four hours after treatment with carrageenan the duration of hexobarbital hypnosis was prolonged and the rate of hepatic hexobarbital metabolism was inhibited. By contrast, treatment with carrageenan potentiates zoxazolamine paralysis time and inhibits zoxazolamine metabolism in both male and female rats. Thus, sex-related differences in the rats bearing carrageenan-induced paw edema and inhibition of drug metabolism are apparently substrate dependent.