Effect of oral administration of sorbitan monostearate on prenatal and postnatal development of the rat
Takada, K.; Momma, J.; Horiuchi, S.; Suzuki, Y.; Tobe, M.
Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 1986(104): 58-64
1986
ISSN/ISBN: 0077-4715 PMID: 3567441 Document Number: 275641
Effects of sorbitan monostearate (Span 60) on prenatal and postnatal development of Slc:Wistar rat were examined. The material was administered by gavage during the whole gestation stage at dose levels of 500 and 1000 mg/kg/day. The results were as follows: 1) Effects on the dams: In the treated groups, no significant changes were observed in their general appearance, fertility index, and number of corpora luteas and implants. 2) Effects on the fetuses: In the treated groups, no significant changes were observed in the number of live fetuses and dead fetuses, sex ratio, body weight, external findings and skeletons. 3) Effects on the offspring: Body weight gain of offspring was suppressed slightly at a dose level of 1000 mg/kg. However, no alterations were observed in little size, viability index on the 4th day, lactation index, external findings and skeletons. It is concluded that Span 60 has no teratogenic effect in rat under the present experimental conditions.