Effect of prenatal administration of T-2 toxin to mice
Stanford, G.K.; Hood, R.D.; Hayes, A.W.
Research Communications in Chemical Pathology and Pharmacology 10(4): 743-746
1975
ISSN/ISBN: 0034-5164 PMID: 1153850 Document Number: 93054
T-2 toxin administered intraperitoneally to mice at 1 and 1.5 mg/kg caused significant maternal mortality and decreased prenatal survival. Foetal weights were reduced on days 7, 10 and 11. Gross malformations involved the tail and limbs, exencephaly, open eye and retarded jaw development occurred particularly in foetuses from females treated on days 9, 10 or 11. Ribs and vertebral malformations were seen in foetuses exposed on days 9 and 10.
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