New aspects in mechanisms of antihypoxic piracetam action
Wustmann, C.; Fischer, H.D.; Rudolph, E.; Schmidt, J.
Biomedica Biochimica Acta 48(2-3): S243-S246
1989
ISSN/ISBN: 0232-766X PMID: 2730617 Document Number: 343763
A long-term piracetam treatment leads to an improved stimulus-effect-coupling of potassium stimulated dopamine release: The maximum effect of the potassium stimulus is already obtained in presence of much lower Ca++-concentrations (Ca++-economizing effect) than normally. In consequence of the improved stimulus-effect-coupling by piracetam treatment the dose-dependent inhibitory effect of the calcium antagonist flunarizine on the fractional efflux rate of dopamine is decreased. The volume of vesicular structures is not involved in the piracetam effect.