Basic and clinical aspects of calcimimetics. Cinacalcet, effect and mechanisms of action
Nakanishi, S.; Fukagawa, M.
Clinical Calcium 18(1): 20-26
2008
ISSN/ISBN: 0917-5857 PMID: 18175867 Document Number: 627738
Calcimimetics drug such as cinacalcet suppress the secretion of parathyroid hormone by sensitizing parathyroid calcium receptors to extracellular ionized calcium. Standard treatment for secondary hyperparathyroidism is associated with the risk of hypercalcemia, but cinacalcet don't induce elevation of serum calcium. And it is reported that cinacalcet attenuates parathyroid hyperplasia and it effects on other organs.