Comparison of GnRH antagonists and flareup GnRH agonists in donor oocyte cycles
Wei, A.Y.; Mijal, K.A.; Christianson, M.S.; Schouweiler, C.M.; Lindheim, S.R.
Journal of Reproductive Medicine 53(3): 147-150
2008
ISSN/ISBN: 0024-7758 PMID: 18441715 Document Number: 627737
OBJECTIVE: To compare the flareup GnRH-antagonist (GnRH-ant) and GnRH-agonist (GnRH-a) protocols in oocyte donation cycles, using the donor as her own control.STUDY DESIGN. A retrospective review at a university-based practice of 22 oocyte donors who underwent 29 cycles using recombinant follicle-stimulating hormone (FSH) and GnRH-ant an 28 cycles using flareup GnRH-a with recombinant FSH. Recipients (n = 57) were synchronized with estrogen and progesterone supplementation.RESULTS: The total number of recombinant FSH used and days of stimulation were similar between the groups; however, cycle days 5 estradiol (341 +/- 40 vs. 473 +/- 62 pg/mL), peak serum estradiol (1,721 +/- 170 vs. 3,625 +/- 295 pg/mL) and the number of retrieved MII oocytes (17 +/- 1.5 vs. 29 7) were significantly higher in the flareup GnRH-a group. Similar fertilization rates, embryos transferred, clinical pregnancy rate/embryo transfer (44%, 11125; vs. 55%, 15/27), delivered pregnancy rate/embryo transfer (32%, 8125; vs. 52 %, 14/2 7) and implantation rates (31 +/- 6% vs. 28 5%) were seen in each group.CONCLUSION: Both the flareup GnRH-a and GnRHant are shortened, simplified and efficacious protocols in oocyte donation cycles.