Comparison of GnRH antagonist protocol with or without oral contraceptive pill pretreatment and GnRH agonist low-dose long protocol in low responders undergoing IVF/intracytoplasmic sperm injection

Kim, C.-H.; Jeon, G.-H.; Cheon, Y.-P.; Jeon, I.; Kim, S.-H.; Chae, H.-D.; Kang, B.-M.; Kim, C.-H; Jeon, G.-H; Cheon, Y.-P; Jeon, I; Kim, S.-H; Chae, H.-D; Kang, B.-M

doi:10.1016/j.fertnstert.2009.05.013

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Comparison of GnRH antagonist protocol with or without oral contraceptive pill pretreatment and GnRH agonist low-dose long protocol in low responders undergoing IVF/intracytoplasmic sperm injection

Kim, C.-H.; Jeon, G.-H.; Cheon, Y.-P.; Jeon, I.; Kim, S.-H.; Chae, H.-D.; Kang, B.-M.

Fertility and Sterility 92(5): 1758-1760

2009

ISSN/ISBN: 1556-5653

PMID: 19523618

DOI: 10.1016/j.fertnstert.2009.05.013

Document Number: 206047

This prospective randomized study was performed to compare the efficacy of GnRH antagonist multiple-dose protocol (MDP) with or without oral contraceptive pill (OCP) pretreatment and GnRH agonist low-dose long protocol (LP) in 82 patients undergoing IVF/intracytoplasmic sperm injection (ICSI). GnRH antagonist MDP with OCP pretreatment was at least as effective as GnRH agonist low-dose LP in low responders, and can benefit the low responders by reducing the amount of FSH and the number of days of stimulation required for follicular maturation.