Biochemical mechanisms of the antihypoxic effect of amichlorphen (diethylaminoethylamide parachlorphenoxyacetic acid)
Zakharevskiĭ, A.S.; Smelianskaia, G.N.; Saksonov, P.P.; Shadurskiĭ, K.S.; Tamarina, N.Z.
Farmakologiia i Toksikologiia 39(1): 108-114
1976
ISSN/ISBN: 0014-8318 PMID: 943311 Document Number: 108878
Test set up on albino rats demonstrated a preliminary introduction of amichlophene to prevent a hypoxic fall in the level of highly ergastic compounds in the tissues owing to stimulation of the mitochondrial respiration processes and increased energy-producting effectiveness of the latter. The beneficial effect of amichlophen on the bioenergetics of the tissues in acute hypoxia is largely caused by the continued structural and functional integrity of the mitochondria, lysosomes and other cellular organellae which is due to the inhibitory action of the compound on the prosses of lipids reoxidation and to the activity of phospholipase A.