Mechanisms of the stimulating effect of d-glucuronic acid on the processes of bone marrow granulomonocytopoiesis in cytostatic myelodepression

Gol'dberg, E.D.; Dygaĭ, A.M.; Karpova, G.V.; Simanina, E.V.; Khlusov, I.A.; Shakhov, V.P.; Agafonov, V.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 115(4): 350-352

1993


ISSN/ISBN: 0365-9615
PMID: 8049386
Document Number: 417943
The mechanisms of regulating influence of D-glucuronic acid on granulomonocytopoiesis++ have been studied by using the model of cyclophosphamide-induced myelodepression. Increase of colony-stimulating and interleukin-1 activities production by hemopoiesis inducing microenvironment cells, the stimulation of hemopoietic islets and the different granulomonocytopoiesis precursor cells forming have been shown to be the base of activating action of D-glucuronic acid on bone marrow granulomonocytopoiesis recovery.

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