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Antiallergic effect of D-glucuronic acid

Danilets, M.G.; Bel'skiĭ, I.P.; Bel'skaia, N.F.; Trofimova, E.S.; Uchasova, E.G.; Ligacheva, A.A.; Agafonov, V.I.

Eksperimental'naia i Klinicheskaia Farmakologiia 71(5): 37-39

2008

ISSN/ISBN: 0869-2092
PMID: 19093370
Document Number: 617028
The influence of D-glucuronic acid (course administration) on a Thl and Th2 immune response was studied. It is established that D-glucuronic acid suppressed Th2-dependent immune response as it decreased the lethality from the anaphylactic shock, abolished the local anaphylactic reaction and strongly inhibited allergen-specific IgE and IgG1 production. In addition, D-glucuronic acid stimulated Thl-dependent immune response since it enhanced the delay-type hypersensitivity reaction, increased amount of antibody-forming cells and the number of antibodies in blood. It is concluded that the mechanism of the antiallergic effect of D-glucuronic acid is related to a change in the Th1/Th2 balance in favor of Th1.

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