Preclinical toxicological study of D-glucuronic acid
Karpova, G.V.; Fomina, T.I.; Vetoshkina, T.V.; Borovskaia, T.G.; Voronova, O.L.; Dubskaia, T.I.; Udut, V.V.; Khlusova, M.I.
Eksperimental'naia i Klinicheskaia Farmakologiia 64(1): 68-70
2001
ISSN/ISBN: 0869-2092 PMID: 11544811 Document Number: 528569
A new D-glucuronic acid (DGA) preparation was studied for toxicological safety on a preclinical level. The results obtained upon a single acute DGA administration in rats, mice, and rabbis showed that the drug exhibits moderate toxicity. A one-month treatment of rats (at a single daily dose of 50, 250, and 500 mg/kg, i.p.) and dogs (50 mg/kg, i.v.) induced neither functional nor morphological changes in hemopoietic and lymphoid organs, kidney, heart, as well as in the digestive, nervous, hemostatic, and fibrinolytic systems. The intraperitoneal administration of DGA produced a pronounced local irritation effects. The liver of both rats and dogs treated with DGA showed dose-dependent adipose degeneration, which decreased upon the drug abolition. The administration of DGA in 50, 100, and 250 mg/kg doses led to dose-dependent changes in some characteristics of the reproductive system in rats. DGA did not modify the extent of allergic reactions and showed no immunotoxicant and mutagen properties.