Effect of histones on nonenzymatic fibrinolysis in plasma
Liapina, L.A.
Voprosy Meditsinskoi Khimii 35(1): 37-41
1989
ISSN/ISBN: 0042-8809 PMID: 2741397 Document Number: 342523
Histones H2A, H2B, H3 and H5 were shown to be concerned with inhibitors of heparin and its complexes responsible for nonenzymatic fibrinolytic effect on unstabilized fibrin. Inhibitory effect of histones on nonenzymatic fibrinolysis consisted in molecular reaction of proteins or amines substitution as well as in development of inactive complexes with heparin. Arginine residues of histones appear to be involved in complex formation with heparin.
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