Plasma Lp (a) levels and correlation of Lp (a) with fibrinolysis activation in chronic renal failure
Zhu, J.; Xiong, X.; Zhao, S.; Wang, Z.; Lou, L.; Hang, Q.
Hunan Yi Ke da Xue Xue Bao 24(4): 366-368
1999
ISSN/ISBN: 1000-5625 PMID: 12080650 Document Number: 499273
Plasma Lp (a) concentration and activation of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1(PAI-1) were determined in 50 patients with chronic renal failure (CRF) and in 50 healthy subjects. The results demonstrated that plasma concentration of Lp(a) was significantly higher and plasma t-PA activation was significantly lower in CRF patients than in healthy subjects. With multivariate analyses, plasma Lp(a) concentration was positively correlated with the total amount of 24 h uric protein, plasma BUN and uric protein concentration. Moreover, a negative significant correlation between plasma Lp(a) levels and t-PA activation was observed. Plasma Lp(a) levels did not show a correlation to PAI-1 activation. It is indicated that renal function may contribute to moderate plasma Lp(a) concentration and elevated Lp(a) levels may be related with fibrinolytic impairment.