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The histamine-liberating action of polymyxin B and its analogs

Bairamashvili, D.I.; Voĭtenko, V.G.; Gushchin, I.S.; Zinchenko, A.A.; Miroshnikov, A.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 107(4): 447-449

1989

ISSN/ISBN: 0365-9615
PMID: 2470441
Document Number: 332477
Histamine-releasing effect of polymyxin B1 and its deacylated analogues has been studied on purified rat mast cells. The structure-activity analysis showed that cyclic peptide fragment and acyl residue of molecule of polymyxin plays an important role in histamine-releasing activity. Histamine release, induced by polymyxin B1 and its analogue was blocked by metabolic inhibitor antimycin A. Preincubation of polymyxin B1 with lipopolysaccharide inhibits in dose-dependent manner polymyxin-induced histamine secretion from rat mast cells.

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