Histamine-liberating action of MCD-peptide from bee venom
Gushchin, I.S.; Miroshnikov, A.I.; Martynov, V.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 84(7): 78-80
1977
ISSN/ISBN: 0365-9615 PMID: 70248 Document Number: 118756
Histamine release (HR) from the isolated rat mast cells induced by MCD-peptide, mellitin (from the Apis mellifica venom) and compound 48/80 was studied. The dose-response curve, the latent period and temperature dependence of HR induced by MCD-peptide were similar to those of HR induced by compound 48/80. The HR induced by MCD-peptide proved to be an energy-dependent process that was independent of cyclic adenosine-3',5'-monophosphate.