Effects of ethanol on the concentration of neuropeptides, ACTH and corticosterone during immobilization stress
Iukhananov, R.I.; Rozhanets, V.V.; Maĭskiĭ, A.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 108(10): 455-457
1989
ISSN/ISBN: 0365-9615 PMID: 2557102 Document Number: 332056
It was shown, that stress increased the level of ACTH, beta-endorphin and corticosterone in the blood plasma of the rat. Injection of ethanol (1 g/kg) decreased the level of ACTH, but increased the levels of beta-endorphin in the rat subjected to immobilization stress. The immobilization lowered the levels of met-enkephalin in the striatum and medulla oblongata, but increased the content of neuropeptide in the adrenal glands. The concentration of leu-enkephalin and DSIP remained unchanged following the stress. Ethanol reversed the action of immobilization on the level of met-enkephalin in the striatum, but increased the content of DSIP in the thalamus. These results indicate that ethanol modified the activity of pituitary-adrenal-axis during stress and probably the stress-protective action of ethanol partly performed with the involvement of DSIP.