Effects of ginseng root saponins on central transmitters and plasma corticosterone in cold stress mice and rats
Cheng, X.J.; Liu, Y.L.; Deng, Y.S.; Lin, G.F.; Luo, X.T.
Zhongguo Yao Li Xue Bao 8(6): 486-489
1987
ISSN/ISBN: 0253-9756 PMID: 2897755 Document Number: 305043
The effects of ginseng root saponins (GRS) on the rectal temperature, plasma corticosterone and central transmitters were studied using mice and rats subjected to a cold stress. When mice were put in -2.degree. C environment for 1 h, the rectal temperature fell significantly. While ig GRS 50 or 100 mg/kg caused a slow fall in rectal temperature of mice in the same condition. The contents of brain NE, 5-HT, 5-HIAA were decreased in mice in -4.degree. C environment for 1 h, and increased in mice after ig GRS 100 mg/kg. But DA showed no change both in cold stress and GRS groups. When rats were put in -2.degree. C for 1 h, the rectal tempeature also fell markedly, the plasma corticosterone increased. While ig GRS 70 mg/kg, the rectal temperature showed no change, the brain ACh and plasma corticosterone increased apparently, but there was no change in brain GABA, Glu and Asp.