Diflucortolone-21-valerate Reference Standard (Control 871) of National Institute of Hygienic Sciences
Tanaka, M.; Hiroshige, R.; Murai, M.; Tokunaga, H.; Okada, S.; Kimura, T.
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences 1989(107): 156-159
1989
ISSN/ISBN: 0077-4715 PMID: 2636922 Document Number: 331619
Diflucortolone-21-valerate was tested for the preparation of "Diflucortolone-21-valerate Reference Standard (Control 871)". Analytical data obtained were as follows: loss on drying, 0.05%; infrared spectrum, 1745, 1727, 1667, 1625, 1611, 1169 cm-1; ultraviolet spectrum, lambda max = 239 nm; absorbance, E1%1cm (239 nm) = 348.8; optical rotation, ɑ20D: + 100.8 degrees; melting point, 203.2 degrees C; thin-layer chromatography, three contaminants were detected; high-performance liquid chromatography, two contaminants were detected; fluorine, 8.06%. On the basis of those results, this material was authorized as the National Institute of Hygienic Sciences Reference Standard (Control 871).