Benzonal metabolism in guinea pigs
Okudzhava, V.M.; Chankvetadze, B.G.; Rogava, M.M.; Dzhikiia, N.I.; Lomsadze, K.T.
Farmakologiia i Toksikologiia 52(3): 71-73
1989
ISSN/ISBN: 0014-8318 PMID: 2792358 Document Number: 328552
A metabolite of an anticonvulsant drug Benzonal was isolated from the guinea pig blood serum and identified by high performance liquid chromatography (HPLC). By using HPLC as well as ultraviolet-, infrared- and mass-spectrometry it was established that in the guinea pig intestine Benzonal undergoes alkaline hydrolysis with the formation of phenobarbital. The native Benzonal in the guinea pig blood serum was not found.
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