Histocompatibility-linked genetic control of the immune response to hapten guinea pig albumin conjugates in inbred guinea pigs
Green, I.; Paul, W.E.; Benacerraf, B.
Journal of Immunology 109(3): 457-463
1972
ISSN/ISBN: 0022-1767 PMID: 5066344 Document Number: 49865
Strain-13 guinea-pigs made significant anti-dinitrophenyl (anti-DNP) antibody responses to 1 mu g of DNP guinea-pig alubumin (GPA), while strain-2 guinea-pigs made little or no response and were not prepared for secondary anti-DNP responses. Progeny of (2X13)X2 matings possessing strain-13 histocompatibility antigens were good responders to a low dose of DNP-GPA, while offspring lacking strain-13 antigens were poor responders. Differential response was also observed with p-iodophenylsulphonyl-GPA and 3-(2,4-dinitrophenylamino)-propylamide-GPA. It is suggested that the autosomal dominant specific immune response gene is closely linked to the gene complex controlling strain-13 histocompatibility antigens, and is involved in carrier recognition, operating in thymus-derived lymphocytes.