Functional state of blood platelets in arterial hypertension and the changes in serotonin-containing cellular granules
Mezhlumian, A.G.; Vikhert, O.A.; Gabbasov, Z.A.; Maĭsov, N.I.; Gavrilov, I.I.; KrotovSN; Arabidze, G.G.; Popov, E.G.
Kardiologiia 29(9): 13-18
1989
ISSN/ISBN: 0022-9040 PMID: 2593466 Document Number: 327377
The study was undertaken to examine the status of the granular apparatus and platelet aggregability in 9 healthy donors and 18 patients with arterial hypertension (AH), including 14 with essential hypertension (EH) and 4 with symptomatic forms of AH. Among the patients, a group of 8 EH patients was singled out, who had, compared with normal, reduced relative volumes of electron dense platelet granules (from 17.9 +/- 2.0 to 5.3 +/- 0.6%). The group also showed lower platelet serotonin levels (from 67.3 +/- 5.3 to 17.6 +/- 3.7 ng per 10(8) cells; p less than 0.001) and a 2-fold decrease in the transport factor of acridine orange across the cytoplasmic and granular membranes as compared to normal. A positive correlation was established between the amounts of cellular serotonin and the relative volume of platelet granules (r = 0.850; p less than 0.001).