Serotonin efflux-inducing effects on human blood platelets by carbamoylpiperidine and nipecotoylpiperazine aggregation inhibitors
Lasslo, A.; Dillingham, E.O.; Gollamudi, R.; Carter-Burks, G.
Research Communications in Chemical Pathology and Pharmacology 58(1): 129-137
1987
ISSN/ISBN: 0034-5164 PMID: 3432730 Document Number: 304593
The serotonin efflux-inducing potency of carbamoylpiperidine and nipectotoylpiperazine aggregation inhibitors was evaluated in human blood platelets. Findings were interpreted in terms of structure-activity relationships, and related to actions exerted by the compounds on other human blood platelet functions. Termination of the active efflux period in the presence and absence of acetylsalicyclic acid allowed assessment of the influence of aspirin on the quenching process.