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The relation of structural and functional status of the left chambers of the heart, the level of circulating NT-pro-BNP and the status of endothelium dependent vasodilation with characteristics of 24 hour blood pressure monitoring in patients with arterial hypertension

Vaĭda, L.S.; Lozyns'ka, N.V.

Likars'ka Sprava 2013(3): 16-24

2013

ISSN/ISBN: 1019-5297
PMID: 25016742
Document Number: 670047
On the certain stage of development of cardiovascular diseases (and not only AH) their further progression depends from the changes of structural and functional status of the left chambers of the heart, the presence of left ventricular hypertrophy (LVH), the functional status of endothelium and plasma concentration of brain natriuretic peptide (some consider the latter is an important prognostic marker of LVH because it takes part in regulation of heart remodeling processes). Because of these we studied the links of mentioned characteristics with the levels of blood pressure (using 24 hour blood pressure monitoring). The analysis of our data showed that higher daytime averag SBP, DBP, PBP are associated with higher concentration of circulating NT-pro-BNP but there is no relationship between mentioned characteristics and EDVD. The daytime average values o SBP > 165 mm Hg, DBP > 98 mm Hg and PBP > 69 mm Hg are linked with higher values of lef ventricular mass index, longer period of LV isovolumic relaxation and significantly higher concentration in plasma of NT-pro-BNP. We did not find statistically significant correlations between daytime average values of SBP, DBP, PBD and LVEF, the dimensions of left chambers of the heart, Doppler indices of diastolic transmitral flow and endothelium dependent vasodilation reaction of a. brachialis (delta %).

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