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Dynamics of the plasma fibronectin level in patients with food poisoning

Pak, S.G.; Bogin, I.B.; Kakhnovskaia, N.L.; Sokurenko, E.V.; Berchenko, V.V.

Terapevticheskii Arkhiv 60(11): 71-75

1988

ISSN/ISBN: 0040-3660
PMID: 3238583
Document Number: 325238
A study was made of the influence of the level and biological activity of plasma fibronectin of phagocytosis and opsonic activity of blood plasma in 147 patients with food toxinfections depending on a period and degree of severity of a course of disease. Plasma fibronectin concentration was determined by rocket immunoelectrophoresis. Fibronectin biological activity was assessed by cold heparin precipitation. Opsonic activity of blood plasma before and after fibronectin inactivation in it was investigated using indices of phagocytosis which was studied by optical microscopy. Food toxinfections were attended by a decrease in the level and biological activity of plasma fibronectin returning to normal during therapy and convalescence. A degree of the reduction of the level of plasma fibronectin reflected the severity of a course of food toxinfections. Phagocytic insufficiency developed in food toxinfections. One of its mechanisms was a decrease in opsonic activity of plasma fibronectin as a result of the reduction of its level.

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