The stability of aqueous solutions of phenylephrine at elevated temperatures: identification of the decomposition products
Millard, B.J.; Priaulx, D.J.; Shotton, E.
Journal of Pharmacy and Pharmacology 25(Suppl): 24p
1973
ISSN/ISBN: 0022-3573 PMID: 4150588 Document Number: 3246
The decomposition of phenylephrine in buffered solution at pH 6.8 was studied using t.l.c. and g.l.c. The major decomposition products were identified by gas chromatography-mass spectrometry following the formation of the trimethylsilyl derivative and are 1,2,3,4-tetrahydro4,6-dihydroxy-2-methylisoquinoline and the 4ß-dihydroxy analogue. A possible mechanism for the degradation reaction is discussed.
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