Efficacy of clorsulon against Fascioloides magna infection in sheep
Conboy, G.A.; Stromberg, B.E.; Schlotthauer, J.C.
Journal of the American Veterinary Medical Association 192(7): 910-912
1988
ISSN/ISBN: 0003-1488 PMID: 3366676 Document Number: 324392
Clorsulon reduced an experimental Fascioloides magna infection by 62% and severity of lesions by 45.9%. Sheep were inoculated with 100 metacercariae of F. magna, and half were treated with 15 mg of clorsulon/kg of body weight (double the dosage for cattle) 8 weeks after inoculation. Sixteen weeks after inoculation, sheep were killed, flukes were recovered, and severity of infection was measured. Currently, the only FDA-approved compound for the removal of flukes (Fasciola hepatica) is clorsulon. There are no approved compounds against F. magna or for use in sheep. It is recommmended that sheep should be treated with clorsulon after the first killing frost (October, November), with a second dose administered one month later in endemic areas.