The persistence of the efficacy of injectable or oral moxidectin against Teladorsagia, Haemonchus and Trichostrongylus species in experimentally infected sheep
Kerboeuf, D.; Hubert, J.; Cardinaud, B.; Blond-Riou, F.
Veterinary Record 137(16): 399-401
1995
ISSN/ISBN: 0042-4900 PMID: 8545937 Document Number: 443984
The persistence of the efficacy of moxidectin was evaluated against experimental gastrointestinal nematode infections in 11 groups of 5 lambs infected on day 0. Moxidectin 1% injectable solution was given at a dose rate of 0.2 mg moxidectin/kg body weight to 5 of the groups on days -42, -35, -28, -21 and -14; 5 other groups were treated with moxidectin 0.1% oral drench at the same dose rate on days -35, -28, -21 and -14 and -7, and the 11th group remained untreated as a control. The lambs were infected experimentally with 8000 Teladorsagia circumcincta, 2000 Haemonchus contortus and 10 000 Trichostrongylus colubriformis infective larvae and killed 3 weeks later. Both formulations of moxidectin showed excellent activity against T. circumcincta and H. contortus with almost 100% efficacy against the abomasal parasites for up to 35 days after treatment. The efficacy of moxidectin 1% injectable against T. colubriformis was much higher (>99%) than that of the oral drench and it was highly effective up to 21 days after treatment, and gave a moderate reduction in worm burden for up to 35 days after treatment. No adverse reactions to moxidectin were observed in any of the animals.