Pharmacokinetics of amoxicillin trihydrate in sheep infected experimentally with Corynebacterium pyogenes and Escherichia coli
Drumev, D.; Koĭchev, K.; Lashev, L.; Borisov, I.
Veterinarno-Meditsinski Nauki 22(5): 85-89
1985
ISSN/ISBN: 0324-1068 PMID: 3898563 Document Number: 267044
A comparative experiment was carried out with sheep that were infected i/v and via the joints with Corynebacterium pyogenes and Escherichia coli, and with normal sheep left as controls. The pharmacokinetic parameters were determined of amoxicillin-trihydrate following its i/m application to all animals in a 20 percent oil suspension. It was found that there was delayed excretion of the antibiotic, and as a rule it was maintained in higher concentrations in the diseased animals. the differences were likely to be due to changes in the metabolic processes and to injury of the kidneys.