Histological and histochemical effects of tribendimidine on Necator americanus
Yang, Y.Q.; Yang, H.Z.; Ren, H.N.; Cheng, B.Z.
Zhongguo Yao Li Xue Bao 9(3): 264-267
1988
ISSN/ISBN: 0253-9756 PMID: 3213546 Document Number: 324178
A single oral dose of tribendimidine at 100 mg/kg was given to hamsters 55 days pi with ~ 500 N. americanus larvae. Examination of N. americanus 3, 6, 12 and 15 h after treatment, showed that the number of non-mobile parasites increased from 14.0 to 98.0%. Thickening of the body walls occurred and the internal structures appeared indistinct. Cuticular swelling and roughening, muscular vacuolation, microvillus desquamation, epithelial cell degeneration and necrosis were observed 12-15 h after treatment. The ova appeared vacuolated, or were necrotic or disintegrated. The glycogen content, ACP and ATPase activity of the worms decreased markedly 3-6 h after treatment and had decreased to virtually undetectable levels by 12-15 h. It is suggested that the action of tribendimidine on carbohydrate metabolism in N. americanus may account for the observed mortality.