Attenuation of pentylenetetrazol kindling of epileptogenesis in rats by dopaminergic agents
Mehta, V.L.; Bhalla, S.; Wafai, Z.A.
Zhongguo Yao Li Xue Bao 9(1): 7-11
1988
ISSN/ISBN: 0253-9756 PMID: 3188938 Document Number: 323074
Kindling model of seizure development was induced in the rats by chronic administration of pentylenetetrazol. On chronic administration of dopamine receptor agonists such as l-dopa, amphetamine and amantadine, the average convulsive score with pentylenetetrazol was attentuated in biphasic manner. Initial protection from convulsions changed to higher convulsive scores. Chronic administration of dopamine receptor blocking agent such as haloperidol, delayed the development of kindled seizures in contrast to control rats. Metoclopramide, another dopaminergic receptor blocking agent did not attenuate the kindled seizures. These observations lend support to the hypothesis that dopamine plays a role in seizures suppression.