Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol
Schmidt, J.
Biomedica Biochimica Acta 46(4): 267-270
1987
ISSN/ISBN: 0232-766X PMID: 3632650 Document Number: 286407
Repeated administration of pentylenetetrazol (PTZ) once every 48 h in behaviorally active threshold and suprathreshold doses induces a marked enhancement of seizure behavior (kindling phenomenon). In contrast, PTZ in initially subconvulsive doses failed to elicit convulsions more complex than stage 1 seizures. With 40 mg/kg PTZ i.p. kindled rats show in the fully kindled state a marked shift of the dose-response curve for PTZ-seizures to the left. The mean stage 4 dose of PTZ is 40 mg/kg in kindled and 75 mg/kg in non-kindled rats.