The withdrawal syndrome and lipid peroxidation during the chronic administration of narcotic analgesics to rats
Konstantinopol'skiĭ, M.A.; Pirozhkov, S.V.; Solov'eva, A.G.; Panchenko, L.F.; Barkov, N.K.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(1): 21-24
1992
ISSN/ISBN: 0869-2092 PMID: 1363943 Document Number: 404686
Diverse behavioral disorders and the intensity of lipid peroxidation (LPO) of biological membranes were estimated in different rat tissues after the 7-day administration and subsequent withdrawal of morphine or promedol. 24 hours after the withdrawal of the analgetics the demonstrated a high initial level of motor activity in the open field. Naloxone, an antagonist of opiate receptors, potentiated motor activity and the intensity of withdrawal syndrome (by 160%) in rats with morphine rather than promedol dependence. The behavioral disorders in dependent animals were accompanied by LPO activation in liver and brain membranes.