Effect of chronic choline administration in rats
Sahu, A.P.; Saxena, A.K.; Singh, K.P.; Shanker, R.
Indian Journal of Experimental Biology 24(2): 91-96
1986
ISSN/ISBN: 0019-5189 PMID: 3733172 Document Number: 93
As a shadow nutrient, choline is necessary for the normal functioning of the mammalian organism. Choline chloride (CC) was administered (ip) either as 0.0, 0.1, 0.33 or 0.5 .times. LD50 (total 24 injections; 5 day/week) and study continued up to 8 months in rats. The dose of 0.33 .times. LD50 of CC caused significant body weight gain in rats at 8 months. The treatment related changes in the absolute and relative organ weights were observed in different groups of CC treated animals. The lowest or highest dose of CC adversely affected the cellularity of spleen, thymus and peripheral lymph nodes, while the dose of 0.33 .times. LD50 of CC caused increase in splenocyte counts at 8 months. Additional studies with 0.33 .times. LD50 of CC (total 40 injections; 5 day/week) revealed marked pathotoxicologic alterations in lungs, lymph nodes and liver at 6 months. It is interesting that choline which has various vital functions, could lead to adverse effects and pathological lesions in lungs and lymph nodes.
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