Therapeutic effect of orally applied cytidine diphosphate choline in mild and severe degrees of normobaric and normocapnic degrees of hypoxia of rats
Hamdorf, G.; Cervós-Navarro, J.
Arzneimittel-Forschung 41(12): 1206-1210
1991
ISSN/ISBN: 0004-4172 PMID: 1815517 Document Number: 384622
Eighty Wistar rats were maintained under conditions of chronic hypoxic for a period of 5 months. After gradual adaptation to the reduced oxygen content of the inhaled air, animals were kept on the levels of 15, 12, 10 and 7 vol% O2 and their behaviour in an open field was observed. One group of 40 animals received CDP-choline (cytidine diphosphate choline, Somazina; CAS 1477-47-0) at a dose of 100 mg/kg body weight in their food. Hypoxia-induced behavioural deteriorations were partly mitigated by this substance. Therapeutic application of CDP-choline was more effective than prophylactic administration. The efficiency of CDP-choline decreased after prolonged application. Under conditions of extreme hypoxia CDP-choline exhibited a life prolonging effect.