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Effect of coprophagy prevention and antibiotics on choline degradation in rats

Kwong, E.; Barnes, R.H.

Journal of Nutrition 100(7): 711-714

1970

ISSN/ISBN: 0022-3166
PMID: 5466149
Document Number: 25564
The degradation of 200 mg choline per kg body-weight daily, given to male weanling Holtzman rats by intragastric tube, was studied by estimation of total trimethylamine in urine when coprophagy was prevented or rats were given 0.1% penicillin, 0.1% chlortetracycline (CTC), 2% phthalylsulphathioazole (PST) or combinations of penicillin or CTC with PST in the diet. Excretion of trimethylamine was decreased by prevention of coprophagy, by CTC or PST and, to a greater extent, by CTC with PST.

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