Development of pentylenetetrazol kindling model
Wang, L.; Ono, J.; Walson, P.D.
Yao Xue Xue Bao 28(7): 486-489
1993
ISSN/ISBN: 0513-4870 PMID: 8285046 Document Number: 409093
An ideal animal model of chemical kindling mimicking human epilepsy was developed in 28 day-old rats. Rats were given pentylenetetrazol (PTZ) 30 mg/kg, ip, once per day for 28 consecutive days; after stopping treatment for one week, the rats were retreated using the same dose of PTZ until reaching the kindled criterion. The kindled rate was 74%. The behavioral seizure and EEG discharges were synchronized. All kindled rats still kept their high seizure state after the experiments.
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