Role of beta-adrenoceptor antagonists in the control of kindling models in rats
Yue, W.; Zhang, F.; Wang, L.; Liu, Z.T.
Yao Xue Xue Bao 35(12): 886-889
2000
ISSN/ISBN: 0513-4870 PMID: 12567907 Document Number: 517129
To study the role of beta-adrenoceptors (beta-AR) and their subtypes in the control of kindling models in rats. Electrical amygdala kindling, pentylenetetrazol (PTZ) kindling models in rats and maximal electroshock (MES) in mice were used to observe the effects of beta-AR agonists and antagonists. The beta-AR antagonist propranolol 15 mg.kg-1 i.p. delayed the development of amygdala kindling; while propranolol 1-20 mg.kg-1 i.p. and beta-AR antagonist metoprolol 25-400 mg.kg-1 ig significantly increased the afterdischarge threshold and reduced the seizure severity in both kindling models (P < 0.01). beta 1-AR agonist dobutamine completely reversed the inhibitory effect of propranolol, while the beta 2-AR agonist terbutaline showed no effect on propranolol. Metoprolol 200 and 800 mg.kg-1 ig significantly inhibited MES in mice (P < 0.01). Central beta 1-AR is involved in the inhibitory effects on amygdala kindling and PTZ kindling models in rats.