The acute effect of doxorubicin and its analogue--4'-epidoxorubicin on circulatory system in rabbits
Drzewoski, J.; Polakowski, P.; Kaszubski, P.; Orszulak-Michalak, D.
Polish Journal of Pharmacology and Pharmacy 40(2): 159-165
1988
ISSN/ISBN: 0301-0244 PMID: 3237565 Document Number: 322742
The acute influence of doxorubicin (DXR) and its analogue - 4'-epidoxorubicin (4'-epiDXR) on cardiovascular system in rabbits was compared. A single intravenous dose of DXR (1 and 3 mg/kg) did not affect the cardiac index, stroke index and heart rate, but reduced the mean arterial blood pressure and total peripheral resistance. In contrast, 4-epiDXR, in the same doses, did not affect any of the hemodynamic parameters.